{"id":3622,"date":"2024-10-28T14:03:00","date_gmt":"2024-10-28T06:03:00","guid":{"rendered":"https:\/\/www.transplantation.com.cn\/?p=3622"},"modified":"2025-04-01T17:51:16","modified_gmt":"2025-04-01T09:51:16","slug":"%e9%87%8d%e8%a7%86hla-dq%e4%bd%8d%e7%82%b9%e9%94%99%e9%85%8d%e5%af%b9%e7%a7%bb%e6%a4%8d%e8%82%be%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e5%bd%b1%e5%93%8d","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/zh_CN\/2024\/10\/28\/%e9%87%8d%e8%a7%86hla-dq%e4%bd%8d%e7%82%b9%e9%94%99%e9%85%8d%e5%af%b9%e7%a7%bb%e6%a4%8d%e8%82%be%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e5%bd%b1%e5%93%8d\/","title":{"rendered":"\u91cd\u89c6HLA-DQ\u4f4d\u70b9\u9519\u914d\u5bf9\u79fb\u690d\u80be\u6392\u65a5\u53cd\u5e94\u7684\u5f71\u54cd"},"content":{"rendered":"\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"688\" height=\"134\" src=\"http:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94.png\" alt=\"\" class=\"wp-image-3529\" style=\"width:750px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94.png 688w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94-300x58.png 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e0d\u540c\u79cd\u5c5e\u6216\u540c\u79cd\u5c5e\u4e0d\u540c\u7cfb\u522b\u7684\u4e2a\u4f53\u95f4\u8fdb\u884c\u7ec4\u7ec7\/\u5668\u5b98\u79fb\u690d\u65f6\uff0c\u4f1a\u51fa\u73b0\u79fb\u690d\u7ec4\u7ec7\/\u5668\u5b98\u7684\u6392\u65a5\u53cd\u5e94\uff0c\u5176\u672c\u8d28\u662f\u7ec6\u80de\u8868\u9762\u7684\u540c\u79cd\u5f02\u57fa\u56e0\u6297\u539f\u8bf1\u5bfc\u7684\u4e00\u79cd\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u79cd\u4ee3\u8868\u4e2a\u4f53\u7279\u5f02\u6027\u7684\u540c\u79cd\u5f02\u57fa\u56e0\u6297\u539f\u79f0\u4e3a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79fb\u690d\u6297\u539f<\/strong>\u6216<strong>\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f<\/strong>\uff0c\u5176\u4e2d\u80fd\u5f15\u8d77\u5f3a\u70c8\u800c\u8fc5\u901f\u6392\u65a5\u53cd\u5e94\u7684\u6297\u539f\u79f0\u4e3a<strong>\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\uff08major histocompatibility&nbsp;antigen,&nbsp;MHA\uff09<\/strong>\uff0c\u5f15\u8d77\u8f83\u5fae\u5f31\u6216\u7f13\u6162\u6392\u65a5\u53cd\u5e94\u7684\u6297\u539f\u79f0\u4e3a<strong>\u6b21\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\uff08minor histocompatibility antigen,&nbsp;MiHA\uff09\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"796\" height=\"531\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-113.png\" alt=\"\" class=\"wp-image-3624\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-113.png 796w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-113-300x200.png 300w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-113-768x512.png 768w\" sizes=\"auto, (max-width: 796px) 100vw, 796px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e34\u5e8a\u7ec4\u7ec7\/\u5668\u5b98\u79fb\u690d\u4e2d\uff0c\u4e00\u822c\u53ea\u8981MHA\u914d\u578b\u6210\u529f\u5373\u53ef\u8fdb\u884c\u79fb\u690d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MHA\u5728\u4eba\u7c7b\u4e2d\u53c8\u88ab\u79f0\u4e3a<strong>\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\uff08human leukocyte antigen, HLA\uff09\u3002<\/strong><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">HLA\u4e3b\u8981\u5206\u4e3a\u4e24\u7c7b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I\u7c7b\u5305\u62ecHLA-A\u3001HLA-B\u548cHLA-C\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e0e\u5404\u79cd\u7ec4\u7ec7\u7ec6\u80de\u4e2d\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">II\u7c7b\u5305\u62ecHLA-DP\u3001HLA-DQ\u548cHLA-DR\uff0c\u5b58\u5728\u4e8eB\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u6d3b\u5316T\u7ec6\u80de\u4e2d\u3002<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e34\u5e8a\u80be\u79fb\u690d\u4e2d\uff0c\u901a\u5e38\u68c0\u6d4b\u53eaHLA-A\u3001HLA-B\u3001HLA-DR\u4e09\u4e2a\u5206\u5b50\u51716\u4e2a\u4f4d\u70b9\uff0c\u56e0\u4e3a\u65e2\u5f80\u7814\u7a76\u663e\u793a\u8fd9\u4e09\u4e2a\u5206\u5b50\u5f97\u914d\u578b\u60c5\u51b5\u4e0e\u79fb\u690d\u80be\u6392\u65a5\u53cd\u5e94\u5173\u7cfb\u6700\u5bc6\u5207\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u8fd1\uff0c\u56fd\u5916\u7684\u7814\u7a76\u56e2\u961f\u63a2\u7a76\u4e86HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u5bf9\u79fb\u690d\u80be\u6392\u65a5\u53cd\u5e94\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u9009\u53d6\u4e86\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u900f\u6790\u79fb\u690d\u4e2d\u5fc3 2004 \u81f3 2012 \u5e74\u95f4\u7684\u6570\u636e\uff0c\u901a\u8fc7\u6821\u6b63\u540e\u7684 Cox \u56de\u5f52\u6a21\u578b\u63a2\u7a76\u4e86\u4ecd\u65e7\u5b58\u6d3b\u6216\u5df2\u7ecf\u6b7b\u4ea1\u7684\u80be\u79fb\u690d\u53d7\u4f53\u53d1\u751f\u6025\u6027\u6392\u65a5\u53cd\u5e94\u4e0e HLA-DQ \u4f4d\u70b9\u4e0d\u5339\u914d\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8fd1800\u540d\u80be\u79fb\u690d\u60a3\u8005\u63a5\u53d7\u4e86\u8fd13\u5e74\u7684\u5e73\u5747\u968f\u8bbf\u65f6\u95f4\uff0c40.7%\u7684\u60a3\u8005\u672a\u63a5\u53d7\u6216\u63a5\u53d7\u4e86 1 \u4e2a HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u7684\u4f9b\u80be\uff0c59.3%\u7684\u60a3\u8005\u63a5\u53d7\u4e86 2 \u4e2a HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u7684\u4f9b\u80be\u3002<\/strong>\u63a5\u53d71\u4e2a\u62162\u4e2a HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u4f9b\u80be\u79fb\u690d\u7684\u60a3\u8005\u6bd4\u672a\u79fb\u690dHLA-DQ\u4e0d\u5339\u914d\u4f9b\u80be\u7684\u60a3\u8005\u66f4\u5bb9\u6613\u53d1\u751f\u6392\u65a5\u53cd\u5e94\uff08\u665a\u671f\u6392\u65a5\u53cd\u5e94\u591a\u53d1\u751f\u5728\u79fb\u690d6\u4e2a\u6708\u540e\uff09\u4ee5\u53ca\u6297\u4f53\u4ecb\u5bfc\u7684\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6821\u6b63\u4e86\u4f9b\u80be\u8005\u4e0e\u80be\u79fb\u690d\u60a3\u8005\u7684\u5e74\u9f84\u3001\u79cd\u65cf\u3001\u4f9b\u80be\u7c7b\u578b\u3001BMI\u3001\u5e74\u4ee3\u3001HLA-A\u3001B\u3001DR \u4e0d\u5339\u914d\u7684\u6570\u91cf\u3001\u7fa4\u4f53\u53cd\u5e94\u6027\u6297\u4f53\u3001\u80be\u79fb\u690d\u7b49\u5f85\u65f6\u95f4\u3001\u7f3a\u8840\u65f6\u95f4\u3001\u8bf1\u5bfc\u6cbb\u7597\u53ca\u539f\u53d1\u6027\u514d\u75ab\u6291\u5236\u53cd\u5e94\u540e\uff0c<strong>\u968f\u8bbf\u7ed3\u679c\u663e\u793a<\/strong>\uff1a\u4e0e\u65e0HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u7684\u80be\u79fb\u690d\u60a3\u8005\u76f8\u6bd4\uff0c\u79fb\u690d\u4e861\u4e2a\u6216\u80052\u4e2a HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u4f9b\u80be\u7684\u60a3\u8005\uff0c\u672f\u540e\u53d1\u751f\u6025\u6027\u6216\u665a\u671f\u6392\u65a5\u53cd\u5e94\u7684\u6821\u6b63\u540e\u5371\u9669\u6bd4\u5206\u522b\u4e3a 1.54 \u548c 2.85\u3002HLA-DR \u4f4d\u70b9\u80fd\u6709\u6548\u8c03\u8282 HLA-DQ \u4e0d\u5339\u914d\u4e0e\u6297\u4f53\u4ecb\u5bfc\u7684\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56e0\u6b64\uff0c\u5728\u79fb\u690d\u4e861\u4e2a\u6216\u80052\u4e2a HLA-DQ&nbsp;\u4f4d\u70b9\u4e0d\u5339\u914d\u7684\u4f9b\u80be\u60a3\u8005\u8eab\u4e0a\uff0c\u4e0a\u8ff0\u4e24\u8005\u4e4b\u95f4\u7684\u5173\u8054\u7edf\u8ba1\u7ed3\u679c\u66f4\u4e3a\u663e\u8457\uff0c\u6821\u6b63\u540e\u5371\u9669\u503c\u4e3a 2.50\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"795\" height=\"552\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-114.png\" alt=\"\" class=\"wp-image-3625\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-114.png 795w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-114-300x208.png 300w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-114-768x533.png 768w\" sizes=\"auto, (max-width: 795px) 100vw, 795px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u6b64\u7814\u7a76\u4e2d\u6025\u6027\u6392\u65a5\u53cd\u5e94\u589e\u52a0\u7684\u539f\u56e0\u662f HLA-DQ \u4f4d\u70b9\u4e0d\u5339\u914d\uff0c\u5e76\u975e HLA-A\u3001B\u3001DR \u4f4d\u70b9\u9519\u914d\u6216\u539f\u53d1\u6027\u514d\u75ab\u6291\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56e0\u800c\uff0c\u6211\u4eec\u5728\u4e34\u5e8a\u5de5\u4f5c\u4e2d\uff0c\u5728\u672f\u524d\u7ed9\u80be\u79fb\u690d\u60a3\u8005\u8fdb\u884c\u514d\u75ab\u76f8\u5173\u98ce\u9669\u7684\u8bc4\u4f30\u65f6\uff0c\u9664\u4e86\u8981\u91cd\u89c6HLA-A\u3001B\u3001DR \u4f4d\u70b9\u662f\u5426\u5339\u914d\u5916\uff0c\u8fd8\u5e94\u5f53\u91cd\u89c6 HLA-DQ \u4f4d\u70b9\u662f\u5426\u5339\u914d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6587|\u738b\u7ee7\u7eb3 &nbsp;\u7f16\u8f91|\u8d3e\u4ea6\u81e3 &nbsp;\u6444\u5f71|C.M<\/p>\n\n\n\n<div class=\"gspb_button_wrapper gspb_button-id-gsbp-9b0f7c0\" id=\"gspb_button-id-gsbp-9b0f7c0\"><a class=\"wp-block-greenshift-blocks-buttonbox gspb-buttonbox wp-element-button\" href=\"https:\/\/mp.weixin.qq.com\/s\/T5FSAIqf0S_ZuCYGH4jc4Q\" title=\"\u5168\u56fd\u9996\u4f8b\u5c3f\u8def\u611f\u67d3\u6cbb\u7597\u6848\u4f8b\" target=\"_blank\" rel=\"noopener\"><span class=\"gspb-buttonbox-textwrap\"><span class=\"gspb-buttonbox-text\"><span class=\"gspb-buttonbox-title\">\u9605\u8bfb\u539f\u6587<\/span><\/span><span class=\"gspb-buttonbox-icon\"><svg class=\"\" style=\"display:inline-block;vertical-align:middle\" width=\"15\" height=\"15\" viewBox=\"0 0 896 1024\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path style=\"fill:#565D66\" d=\"M436.202 76.202l-39.598 39.598c-9.372 9.372-9.372 24.568 0 33.942l310.26 310.258h-682.864c-13.254 0-24 10.746-24 24v56c0 13.254 10.746 24 24 24h682.864l-310.26 310.26c-9.372 9.372-9.372 24.568 0 33.942l39.598 39.598c9.372 9.372 24.568 9.372 33.942 0l418.828-418.828c9.372-9.372 9.372-24.568 0-33.942l-418.83-418.828c-9.372-9.374-24.568-9.374-33.94 0z\"><\/path><\/svg><\/span><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u4e0d\u540c\u79cd\u5c5e\u6216\u540c\u79cd\u5c5e\u4e0d\u540c\u7cfb\u522b\u7684\u4e2a\u4f53\u95f4\u8fdb\u884c\u7ec4\u7ec7\/\u5668\u5b98\u79fb\u690d\u65f6\uff0c\u4f1a\u51fa\u73b0\u79fb\u690d\u7ec4\u7ec7\/\u5668\u5b98\u7684\u6392\u65a5\u53cd\u5e94\uff0c\u5176\u672c\u8d28\u662f\u7ec6\u80de\u8868\u9762\u7684\u540c\u79cd\u5f02\u57fa\u56e0\u6297\u539f\u8bf1\u5bfc\u7684\u4e00\u79cd\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n","protected":false},"author":1,"featured_media":3626,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-text{display:flex;flex-direction:column}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{box-sizing:border-box}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap>.gspb-buttonbox-icon{display:flex}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg path{fill:#fff!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg{margin:0!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap{display:flex;flex-direction:row;align-items:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-icon{margin-left:13px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{margin-bottom:0;background-color:#226dc2;cursor:pointer;text-decoration:none;color:#fff;border-style:solid;border-width:1px;border-color:#428ad6;box-shadow:0 2px 4px 0 #0000001a}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox a{text-decoration:none}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb_backgroundOverlay{border-top-left-radius:4px;border-top-right-radius:4px;border-bottom-right-radius:4px;border-bottom-left-radius:4px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover{box-shadow:0 3px 9px 0 #12121226;transform:translateY(-2px)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path{transition:all .25s cubic-bezier(.165,.84,.44,1)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:active,.active #gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{transform:translateY(2px)}","footnotes":""},"categories":[103],"tags":[],"class_list":["post-3622","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-103"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/comments?post=3622"}],"version-history":[{"count":1,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3622\/revisions"}],"predecessor-version":[{"id":7055,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3622\/revisions\/7055"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/media\/3626"}],"wp:attachment":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/media?parent=3622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/categories?post=3622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/tags?post=3622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}