{"id":3528,"date":"2024-10-25T16:46:15","date_gmt":"2024-10-25T08:46:15","guid":{"rendered":"https:\/\/www.transplantation.com.cn\/?p=3528"},"modified":"2025-04-01T18:10:01","modified_gmt":"2025-04-01T10:10:01","slug":"%e7%a7%bb%e6%a4%8d%e5%89%8d%e6%b2%bf%ef%bc%9amica%e4%b8%8d%e5%8c%b9%e9%85%8d%e6%88%96%e6%88%90%e7%a7%bb%e6%a4%8d%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e5%8f%91%e7%94%9f%e5%8d%b1%e9%99%a9%e5%9b%a0","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/zh_CN\/2024\/10\/25\/%e7%a7%bb%e6%a4%8d%e5%89%8d%e6%b2%bf%ef%bc%9amica%e4%b8%8d%e5%8c%b9%e9%85%8d%e6%88%96%e6%88%90%e7%a7%bb%e6%a4%8d%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e5%8f%91%e7%94%9f%e5%8d%b1%e9%99%a9%e5%9b%a0\/","title":{"rendered":"\u79fb\u690d\u524d\u6cbf\uff1aMICA\u4e0d\u5339\u914d\u6216\u6210\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u53d1\u751f\u5371\u9669\u56e0\u7d20"},"content":{"rendered":"\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"688\" height=\"134\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94.png\" alt=\"\" class=\"wp-image-3529\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94.png 688w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94-300x58.png 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5404\u4f4d\u80be\u53cb\u82e5\u5bf9\u79fb\u690d\u624b\u672f\u6709\u4e9b\u4e86\u89e3\uff0c\u5fc5\u7136\u660e\u767d\u201c\u914d\u578b\u201d\u662f\u79fb\u690d\u624b\u672f\u4e2d\u7684\u91cd\u8981\u4e00\u73af\u3002\u662f\u5426\u914d\u578b\u6210\u529f\u76f4\u63a5\u5173\u7cfb\u5230\u53d7\u8005\u662f\u5426\u9002\u5408\u63a5\u53d7\u76f8\u5e94\u4f9b\u80be\uff0c\u5339\u914d\u7a0b\u5ea6\u4e5f\u76f4\u63a5\u5173\u7cfb\u5230\u79fb\u690d\u540e\u6392\u65a5\u53cd\u5e94\u7684\u53d1\u751f\u7387\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u90a3\u4e48\u914d\u578b\u5230\u5e95\u5982\u4f55\u5b9e\u73b0\uff1f\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539fHLA\u53c2\u4e0e\u673a\u4f53\u5bf9\u5f02\u5df1\u6210\u5206\u7684\u8bc6\u522b\u8fc7\u7a0b\uff0c\u56e0\u6b64\u79fb\u690d\u4f9b\u53d7\u4f53HLA\u7684\u76f8\u4f3c\u7a0b\u5ea6\u76f4\u63a5\u63d0\u793a\u65e5\u540e\u53d1\u751f\u6392\u65a5\u53cd\u5e94\u7684\u6982\u7387\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u80be\u79fb\u690d\u914d\u578b\u9700\u8981\u5224\u65ad\u4f9b\u53d7\u8005HLA\u662f\u5426\u5339\u914d\uff0c\u5177\u4f53\u624b\u6bb5\u4e3a\u68c0\u6d4b\u4f9b\u53d7\u8005HLA-A\uff0cHLA-B\uff0cHLA-DR\u7b49\u5206\u578b\uff0c\u5e76\u5c06\u4f9b\u53d7\u8005HLA\u5206\u5b50\u7c7b\u578b\u4e00\u4e00\u5bf9\u5e94\u6bd4\u8f83\uff0c\u5339\u914d\u5bf9\u6570\u8d8a\u591a\u6392\u65a5\u53cd\u5e94\u53d1\u751f\u7684\u6982\u7387\u8d8a\u5c0f\u3002\u867d\u7136\u4ee5\u4e0a\u914d\u578b\u65b9\u5f0f\u80fd\u591f\u5927\u5927\u51cf\u5c11\u6392\u65a5\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u4f46\u4ecd\u6709\u5c11\u90e8\u5206\u60a3\u8005\u5728HLA\u5339\u914d\u7684\u60c5\u51b5\u4e0b\u53d1\u751f\u4e86\u6392\u65a5\u53cd\u5e94\uff0c\u4e8e\u662f\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u76ee\u5149\u8f6c\u5411\u4e86\u5176\u4ed6\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\uff0c\u5305\u62ecMICA\u5373\u4eba\u7c7bMHC I\u7c7b\u76f8\u5173\u57fa\u56e0A\u53ca\u5b83\u7f16\u7801\u7684\u591a\u6001\u6027\u975e\u5e38\u89c4MHC I\u7c7b\u5206\u5b50\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"691\" height=\"504\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-95.png\" alt=\"\" class=\"wp-image-3530\" style=\"width:749px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-95.png 691w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-95-300x219.png 300w\" sizes=\"auto, (max-width: 691px) 100vw, 691px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">MICA\u5e76\u4e0d\u662f\u4e00\u4e2a\u65b0\u6982\u5ff5\uff0c\u7814\u7a76\u8005\u4eec30\u5e74\u524d\u5c31\u53d1\u73b0\u4e86\u8fd9\u4e9b\u4e0eMHC I\u7c7b\u94fe\u540c\u6e90\u7684\u5206\u5b50\uff0c\u4f46\u662f\u4e00\u76f4\u6ca1\u80fd\u660e\u786e\u5176\u5728\u79fb\u690d\u540e\u6392\u65a5\u53cd\u5e94\u4e2d\u626e\u6f14\u7684\u89d2\u8272\u3002MICA\u662fHLA-B\u7684\u90bb\u5c45\uff0c\u5e76\u4e14\u56e0\u6b64\u4e0eHLA-B\u7684\u7c7b\u578b\u5e38\u5e38\u7d27\u5bc6\u8054\u7cfb\uff0c\u4f46\u4e5f\u5b58\u5728MICA\u5355\u4e00\u6539\u53d8\u7684\u60c5\u51b5\uff0c\u5e38\u89c4\u7684\u914d\u578b\u5b9e\u9a8c\u5e76\u4e0d\u80fd\u5224\u65adMICA\u7684\u5339\u914d\u7a0b\u5ea6\u53ca\u5206\u578b\u3002\u90a3\u4e48\u5355\u53e6\u68c0\u6d4bMICA\u662f\u5426\u6709\u5fc5\u8981\u5462\uff1f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2022\u5e745\u6708Carapito\u53ca\u5176\u56e2\u961f\u5728\u300anature medicine\u300b\u53d1\u8868\u8bba\u6587\uff0c\u63d0\u51fa\u68c0\u6d4bMICA\u8868\u578b\u662f\u5426\u5339\u914d\u80fd\u591f\u51cf\u5c11\u6f5c\u5728\u7684\u79fb\u690d\u7269\u4e22\u5931\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e86\u6cd5\u56fd6\u4e2a\u4e2d\u5fc31356\u540d\u80be\u79fb\u690d\u60a3\u8005\uff0c\u89c2\u5bdf\u65f6\u95f4\u4e2d\u4f4d\u6570\u4e3a6.3\u5e74\uff0c\u6700\u957f\u65f6\u95f4\u4e3a12.9\u5e74\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cMICA\u4e0d\u5339\u914d\u60a3\u8005\u79fb\u690d\u72695\u5e74\u5b58\u6d3b\u7387\u4e3a88%\uff0c\u663e\u8457\u4f4e\u4e8eMICA\u5339\u914d\u60a3\u8005\uff0c\u5176\u4e2dMICA\u4e0d\u5339\u914d\u4f4d\u70b9&gt;2\u7684\u60a3\u8005\uff0c\u672f\u540e5\u5e74\u5185\u79fb\u690d\u7269\u4e22\u5931\u6982\u7387\u66f4\u5927\u3002\u7814\u7a76\u8fd8\u53d1\u73b0\u65b0\u751f\u6297\u4f9b\u8005MICA\u7279\u5f02\u6027\u6297\u4f53\uff08de novo anti-MICA DSA\uff09\u662fT\u7ec6\u80de\u4ecb\u5bfc\u7684\u6392\u65a5\u53cd\u5e94\uff08TCMR\uff09\u4e0e\u6297\u4f53\u4ecb\u5bfc\u7684\u6392\u65a5\u53cd\u5e94\uff08\uff09ABMR\uff09\u53d1\u751f\u7684\u5171\u540c\u5371\u9669\u56e0\u7d20[1]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0a\u7814\u7a76\u7ed3\u679c\u5411\u6211\u4eec\u63ed\u793a\u4e86\u672f\u524dMICA\u914d\u578b\u68c0\u6d4b\u7684\u91cd\u8981\u6027\uff0c\u76ee\u524d,\u56fd\u5916\u90e8\u5206\u79fb\u690d\u4e2d\u5fc3\u5df2\u7ecf\u5f00\u59cb\u8ba1\u5212\u9010\u6b65\u5c06MICA\u57fa\u56e0\u5206\u578b\u548cDSA\u68c0\u6d4b\u7eb3\u5165\u79fb\u690d\u5019\u9009\u8005\u672f\u524d\u68c0\u67e5\u53ca\u79fb\u690d\u53d7\u8005\u672f\u540e\u62a4\u7406[2]\u3002\u672c\u4e2d\u5fc3\u5df2\u5c06MICA\u6297\u4f53\u6c34\u5e73\u68c0\u6d4b\u4f5c\u4e3a\u79fb\u690d\u53d7\u8005\u672f\u540e\u8bc4\u4f30\u7684\u5de5\u5177\u4e4b\u4e00\uff0c\u4e5f\u5c06\u7ee7\u7eed\u5173\u6ce8\u56fd\u5185\u5916\u65b0\u6280\u672f\u4e0e\u65b0\u7b56\u7565\u7684\u5e94\u7528\uff0c\u53ca\u65f6\u66f4\u65b0\u4e34\u5e8a\u4f53\u7cfb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[1]Carapito,R.,et al.,The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation.Nature Medicine,2022.28(5):p.989-998.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2]Allison,S.J.,MICA in kidney transplants.Nature Reviews.Nephrology,2022.18(5):p.273.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u6587\u4e3a\u201c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\u80be\u79fb\u690d\u201d\u516c\u4f17\u5fae\u4fe1\u53f7\u539f\u521b\u6587\u7ae0\uff0c\u8f6c\u8f7d\u9700\u7ecf\u672c\u5fae\u4fe1\u53f7\u548c\u539f\u6587\u4f5c\u8005\u6388\u6743\u5e76\u6807\u660e\u51fa\u5904\u3002\u5173\u7231\u80be\u810f\uff0c\u4ece\u5173\u6ce8\u201c<strong>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\u80be\u79fb\u690d<\/strong>\u201d\u516c\u4f17\u5fae\u4fe1\u53f7\u5f00\u59cb\uff0c\u60a8\u4e5f\u53ef\u4ee5\u70b9\u51fb<strong>\u3010\u9605\u8bfb\u539f\u6587\u3011<\/strong>\uff0c\u67e5\u770b<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE1MjQzNQ==&amp;mid=2652806584&amp;idx=1&amp;sn=d4cd0b5885999bc1f2d0efad91b2e80d&amp;chksm=80fbf424b78c7d3265dd0a20e4b1a7db12fca358665dc6f552183c2a447738fff798f5f41b29&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u6d3b\u4f53\u4eb2\u5c5e\u4f9b\u80be\u79fb\u690d\u7cfb\u5217\u79d1\u666e\u56de\u987e<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"692\" height=\"357\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-96.png\" alt=\"\" class=\"wp-image-3531\" style=\"width:749px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-96.png 692w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-96-300x155.png 300w\" sizes=\"auto, (max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n\n\n<div class=\"gspb_button_wrapper gspb_button-id-gsbp-9b0f7c0\" id=\"gspb_button-id-gsbp-9b0f7c0\"><a class=\"wp-block-greenshift-blocks-buttonbox gspb-buttonbox wp-element-button\" href=\"https:\/\/mp.weixin.qq.com\/s\/EcfU1GaJ4QoukiRiKUs3hw\" title=\"\u5168\u56fd\u9996\u4f8b\u5c3f\u8def\u611f\u67d3\u6cbb\u7597\u6848\u4f8b\" target=\"_blank\" rel=\"noopener\"><span class=\"gspb-buttonbox-textwrap\"><span class=\"gspb-buttonbox-text\"><span class=\"gspb-buttonbox-title\">\u9605\u8bfb\u539f\u6587<\/span><\/span><span class=\"gspb-buttonbox-icon\"><svg class=\"\" style=\"display:inline-block;vertical-align:middle\" width=\"15\" height=\"15\" viewBox=\"0 0 896 1024\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path style=\"fill:#565D66\" d=\"M436.202 76.202l-39.598 39.598c-9.372 9.372-9.372 24.568 0 33.942l310.26 310.258h-682.864c-13.254 0-24 10.746-24 24v56c0 13.254 10.746 24 24 24h682.864l-310.26 310.26c-9.372 9.372-9.372 24.568 0 33.942l39.598 39.598c9.372 9.372 24.568 9.372 33.942 0l418.828-418.828c9.372-9.372 9.372-24.568 0-33.942l-418.83-418.828c-9.372-9.374-24.568-9.374-33.94 0z\"><\/path><\/svg><\/span><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- wp:image {\"id\":3529,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-94.png\" alt=\"\" class=\"wp-imag...\n<\/p>\n","protected":false},"author":1,"featured_media":3532,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-text{display:flex;flex-direction:column}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{box-sizing:border-box}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap>.gspb-buttonbox-icon{display:flex}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg path{fill:#fff!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg{margin:0!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap{display:flex;flex-direction:row;align-items:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-icon{margin-left:13px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{margin-bottom:0;background-color:#226dc2;cursor:pointer;text-decoration:none;color:#fff;border-style:solid;border-width:1px;border-color:#428ad6;box-shadow:0 2px 4px 0 #0000001a}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox a{text-decoration:none}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb_backgroundOverlay{border-top-left-radius:4px;border-top-right-radius:4px;border-bottom-right-radius:4px;border-bottom-left-radius:4px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover{box-shadow:0 3px 9px 0 #12121226;transform:translateY(-2px)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path{transition:all .25s cubic-bezier(.165,.84,.44,1)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:active,.active #gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{transform:translateY(2px)}","footnotes":""},"categories":[103],"tags":[],"class_list":["post-3528","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-103"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/comments?post=3528"}],"version-history":[{"count":1,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3528\/revisions"}],"predecessor-version":[{"id":7070,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/posts\/3528\/revisions\/7070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/media\/3532"}],"wp:attachment":[{"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/media?parent=3528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/categories?post=3528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/zh_CN\/wp-json\/wp\/v2\/tags?post=3528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}