Introduction to relative kidney transplantation

Overview

The relative kidney transplantation is to take a kidney from a healthy relative body and transplant it to the kidney transplant surgery in patients with uremia.Due to the severe shortage of kidney sources, relative kidney transplantation has become an important source of kidney supply and an important supplement to donation of organs of citizens, in order to alleviate the increasingly increasing demand for kidney transplantation and kidney shortage.

Kinship requirements

In relative kidney transplantation, the recipient and donor usually need to meet certain kinship relationships, including parents, children, and spouses. For specific kinship relationships, please click here. The closeness of these kinship relationships helps increase the success rate of tissue typing and reduce the risk of immune rejection.

Pre -surgery evaluation

Before renal transplantation surgery, suppliers and recipients need comprehensive and detailed medical evaluation to ensure the safety and success of the operation.Preoperative examinations include: blood type matching, tissue matching, health assessment, psychological evaluation, etc.

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Postoperative management

Postoperative management is essential for long -term survival of the transplantation of kidney and even patients.The recipient needs to conduct regular medical examinations to monitor the concentration and effect of renal function and immunosuppressive drugs.At the same time, maintain a healthy lifestyle, including taking medicine on time, a balanced diet, moderate exercise and avoiding infection.

Quality of life

Relative kidney transplantation can significantly improve the quality of life of patients. Successful kidney transplantation can restore normal kidney function, allowing them to resume daily activities and work. In addition, the donor can quickly recover their health and continue to live a normal life after surgery.

Kinship kidney transplantation is an effective and safe method of kidney transplantation, bringing new hope to many patients with renal failure. As one of the earliest units in China to carry out relative kidney transplantation, the Kidney Transplantation Department of Zhongshan Hospital affiliated with Fudan University is committed to providing the highest quality medical services and helping patients regain their lives.

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The advantage of living relatives’ kidney transplantation

Kinship kidney donation has shown significant advantages in multiple aspects.

Genetic factor matching

In kidney transplantation, the matching degree of human white blood cell antigen (HLA) between the supply and recipient is often high.This genetic matching helps reduce the patient’s rejection of the rejection of the new kidney, thereby reducing the risk of rejection after transplantation.Due to the genetic similarity between relatives, the transplantation of the kidneys is more likely to be accepted by the receptor’s body, which improves the success rate of transplantation and long -term survival.

High quality of kidney supply

The quality of donor kidneys mainly depends on the length of their hot and cold ischemia time. Kinship donor kidneys significantly shorten the hot and cold ischemia time compared to DCD donor kidneys, minimizing ischemia-reperfusion injury to the greatest extent possible and ensuring good donor kidney quality, resulting in rapid and good recovery of transplanted kidney function after surgery.

Strong emotional connection

The coordination and communication between relatives are more closely, which helps ensure the perfect implementation of pre -surgery.The emotional connections and support between relatives have a positive impact on recovery of receptors and physical and mental health.

Reduced time and economic costs

Living relative kidney transplantation significantly shortens the waiting time for patients. Compared to DCD donor kidneys, living relative kidney transplantation can be performed quickly after both the donor and recipient are ready, thereby avoiding long waiting times and related health risks, accelerating the treatment process, and improving the quality of life. At the same time, relative kidney transplantation reduces the economic burden on patients. In addition, the incidence of transplant kidney rejection after living relative kidney transplantation is relatively low, and the dosage of postoperative immunosuppressants is relatively small.

The safety of kidney donors is relatively high

In recent years, the perioperative mortality rate of relative kidney donors has dropped to extremely low levels, and the short-term glomerular filtration rate after surgery is roughly 65-70% of preoperative levels. In the long run, there is no significant difference in the mortality rate of kidney donors compared to the general population. Recent studies have even found that the mortality rate of live kidney donors is lower than that of the general population in terms of cardiovascular related deaths. Therefore, living relatives who meet the criteria for kidney transplantation are safe, and kidney donors who follow medical advice have no significant decline in kidney function after surgery.

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The risk of living relative kidney transplantation

Live relative kidney transplantation is also accompanied by some potential risks and challenges. The Department of Kidney Transplantation at Zhongshan Hospital affiliated to Fudan University is committed to helping patients respond to these challenges to ensure the health and safety of the supply and receptor.

The risks and challenges of donors

Surgery -related risk
When the supply is undergoing renal resection, the risk of infection, bleeding and organ injury may be faced, but it can usually be well controlled.

Postoperative complications
After donating a kidney, the remaining kidneys need to bear all functions, and complications such as hypertension and renal dysfunction may occur.

Psychological burden
1. Donation of the kidneys is a major decision, and the supply of the body may face psychological pressure such as worry about postoperative health.Risk of metabolic diseases
2. Supply body may increase the risk of metabolic diseases (such as diabetes and hyperlipidemia) after donation, so long -term health monitoring and lifestyle management are particularly important.

Risk and challenge of receptor

Risk of rejection reaction
Even if genetic similarity between relatives reduces the risk of rejection, recipients still need to take immunosuppressive drugs for a long time to prevent the immune system from attacking the transplanted kidney.

The side effects of immunosuppressive drugs
Long -term taking immunosuppressive drugs may increase the risk of infection, tumor, diabetes and other metabolic diseases.

Postoperative complications
Hypertension, diabetes and other complications may occur after receptor surgery, and even chronic damage to the kidney transplantation (such as interior fibrosis and small tubular atrophy) may occur.

Drug compliance problem
Receptors need to take a variety of immunosuppressive drugs for a long time, but some receptors may not strictly follow the drug use plan due to the side effects, cost burdens or other reasons, which will increase the risk of exclusion reactions and other complications.

Psychological burden


The recovery of postoperative surgery is accompanied by huge psychological pressure. The receptor may worry about the survival of the kidney and the quality of the postoperative life.

For the possible risks and challenges mentioned above, the Kidney Transplantation Department of Zhongshan Hospital affiliated with Fudan University will conduct detailed disease and anatomical assessments for the donor and recipient before surgery, using advanced surgical techniques to reduce trauma and ensure smooth surgery; After the surgery, our medical team (doctors, nurses, and pharmacists) will closely monitor the patients and promptly address any issues; In addition, the kidney transplant team also combines artificial intelligence to provide full lifecycle health management for recipients. We will accompany both donors and recipients throughout the process, ensuring their health and quality of life are maximally protected through comprehensive medical management and psychological support.

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