{"id":3696,"date":"2024-10-28T15:24:48","date_gmt":"2024-10-28T07:24:48","guid":{"rendered":"https:\/\/www.transplantation.com.cn\/?p=3696"},"modified":"2025-04-01T16:49:46","modified_gmt":"2025-04-01T08:49:46","slug":"%e6%bb%a4%e6%b3%a1%e6%a0%b7t%e8%be%85%e5%8a%a9%e7%bb%86%e8%83%9e-%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%b2%bb%e7%96%97%e7%9a%84%e6%96%b0%e9%9d%b6%e6%a0%87","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/en_US\/2024\/10\/28\/%e6%bb%a4%e6%b3%a1%e6%a0%b7t%e8%be%85%e5%8a%a9%e7%bb%86%e8%83%9e-%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%b2%bb%e7%96%97%e7%9a%84%e6%96%b0%e9%9d%b6%e6%a0%87\/","title":{"rendered":"Follicular T Helper Cells: A New Target for Immunosuppressive Therapy"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>October 28, 2024, Immune Tolerance<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"688\" height=\"130\" src=\"http:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124.png\" alt=\"\" class=\"wp-image-3670\" style=\"width:751px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124.png 688w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124-300x57.png 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"685\" height=\"393\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-133.png\" alt=\"\" class=\"wp-image-3697\" style=\"width:750px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-133.png 685w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-133-300x172.png 300w\" sizes=\"auto, (max-width: 685px) 100vw, 685px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years, antibody-mediated rejection has emerged as a primary cause of graft dysfunction.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In humoral immunity, follicular T helper cells play a crucial role in the germinal center, where they facilitate the differentiation of naive B cells into memory B cells and antibody-secreting plasma cells. In this manner, they contribute to the production of donor-specific antibodies, which are the primary cause of antibody-mediated rejection in kidney transplants.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our research at the Kidney Transplantation Center of Zhongshan Hospital, affiliated with Fudan University, demonstrated that the number and proportion of follicular T helper cells increase during rejection episodes, directly correlating with B-cell activation and antibody secretion. However, when rejection is intervened upon, the opposite outcome is observed, further confirming the critical role of follicular T helper cells in rejection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recent articles published in <em>Frontiers in Immunology<\/em> have reviewed and explored the potential applications of follicular T helper cells in kidney transplantation. Follicular T helper cells express several key targets, such as IL-6R, IL-21R, CD40L, and PD-1, among others.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The effects of several novel immunosuppressants targeting these markers on antibody-mediated rejection in kidney transplantation are under investigation, including belatacept, which we discussed earlier, as well as anti-inflammatory agents in the treatment of kidney transplant rejection, and numerous experimental drugs that have not yet entered clinical use. It is anticipated that the research outcomes of these drugs could offer a breakthrough in addressing antibody-mediated rejection.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"688\" height=\"361\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-134.png\" alt=\"\" class=\"wp-image-3698\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-134.png 688w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-134-300x157.png 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Written by | Zhu Dong, Edited by | Zhu Dong, Photography | Greg<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">This article is an original publication of the \u201cKidney Transplantation, Zhongshan Hospital, Fudan University\u201d WeChat public account. Reproduction requires authorization from this account and the original author, with proper attribution. To care for your kidneys, begin by following the \u201cKidney Transplantation, Zhongshan Hospital, Fudan University\u201d WeChat public account. You can also click [Read the Original] to explore other articles in this issue.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"686\" height=\"350\" src=\"http:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126.png\" alt=\"\" class=\"wp-image-3672\" style=\"width:750px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126.png 686w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126-300x153.png 300w\" sizes=\"auto, (max-width: 686px) 100vw, 686px\" \/><\/figure>\n\n\n\n<div class=\"gspb_button_wrapper gspb_button-id-gsbp-9b0f7c0\" id=\"gspb_button-id-gsbp-9b0f7c0\"><a class=\"wp-block-greenshift-blocks-buttonbox gspb-buttonbox wp-element-button\" href=\"https:\/\/mp.weixin.qq.com\/s\/4Iegyc1n9Dmk_Ddp8hV_Xg\" title=\"\u5168\u56fd\u9996\u4f8b\u5c3f\u8def\u611f\u67d3\u6cbb\u7597\u6848\u4f8b\" target=\"_blank\" rel=\"noopener\"><span class=\"gspb-buttonbox-textwrap\"><span class=\"gspb-buttonbox-text\"><span class=\"gspb-buttonbox-title\">Read the original article<\/span><\/span><span class=\"gspb-buttonbox-icon\"><svg class=\"\" style=\"display:inline-block;vertical-align:middle\" width=\"15\" height=\"15\" viewBox=\"0 0 896 1024\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path style=\"fill:#565D66\" d=\"M436.202 76.202l-39.598 39.598c-9.372 9.372-9.372 24.568 0 33.942l310.26 310.258h-682.864c-13.254 0-24 10.746-24 24v56c0 13.254 10.746 24 24 24h682.864l-310.26 310.26c-9.372 9.372-9.372 24.568 0 33.942l39.598 39.598c9.372 9.372 24.568 9.372 33.942 0l418.828-418.828c9.372-9.372 9.372-24.568 0-33.942l-418.83-418.828c-9.372-9.374-24.568-9.374-33.94 0z\"><\/path><\/svg><\/span><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- wp:paragraph --><\/p>\n<p><strong>October 28, 2024, Immune Tolerance<\/strong><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image {\"id\":3670,\"width\":\"751px\",\"height\":\"auto\",\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block... \n\n","protected":false},"author":1,"featured_media":3699,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-text{display:flex;flex-direction:column}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{box-sizing:border-box}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap>.gspb-buttonbox-icon{display:flex}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg 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