{"id":3684,"date":"2024-10-28T15:15:21","date_gmt":"2024-10-28T07:15:21","guid":{"rendered":"https:\/\/www.transplantation.com.cn\/?p=3684"},"modified":"2025-04-01T16:57:10","modified_gmt":"2025-04-01T08:57:10","slug":"%e6%bb%a4%e6%b3%a1%e7%8a%b6t%e8%b0%83%e8%8a%82%e7%bb%86%e8%83%9e%e4%b8%8e%e8%82%be%e7%a7%bb%e6%a4%8d%e6%8a%97%e4%bd%93%e4%bb%8b%e5%af%bc%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e5%85%b3%e7%b3%bb","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/en_US\/2024\/10\/28\/%e6%bb%a4%e6%b3%a1%e7%8a%b6t%e8%b0%83%e8%8a%82%e7%bb%86%e8%83%9e%e4%b8%8e%e8%82%be%e7%a7%bb%e6%a4%8d%e6%8a%97%e4%bd%93%e4%bb%8b%e5%af%bc%e6%8e%92%e6%96%a5%e5%8f%8d%e5%ba%94%e7%9a%84%e5%85%b3%e7%b3%bb\/","title":{"rendered":"Relationship Between Follicular T Regulatory Cells and Antibody-Mediated Rejection in Kidney Transplantation"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>October 28, 2024, Immune Tolerance<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"688\" height=\"130\" src=\"http:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124.png\" alt=\"\" class=\"wp-image-3670\" style=\"width:750px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124.png 688w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-124-300x57.png 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">After decades of advancement, kidney transplantation has become a highly mature treatment for uremia. The management of various complications now includes more appropriate treatment strategies. For instance, rejection, a major concern for patients, can typically be reversed with timely intervention. However, antibody-mediated rejection, particularly chronic antibody-mediated rejection, remains a primary obstacle to the long-term survival of kidney allografts.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"687\" height=\"470\" src=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-130.png\" alt=\"\" class=\"wp-image-3685\" style=\"width:748px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-130.png 687w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-130-300x205.png 300w\" sizes=\"auto, (max-width: 687px) 100vw, 687px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Follicular T regulatory cells<\/strong> can effectively regulate the human immune system, but its function and mechanism are still unclear. Recent studies have shown that the proportion of follicular t regulatory cells is closely related to chronic antibody-mediated rejection in renal transplantation. Eighty-eight renal transplant patients were included in the study, of whom 40 had antibody-mediated rejection and 48 had no antibody-mediated rejection. The percentage of follicular T regulatory cells in graft tissue and peripheral blood was significantly lower in the antibody-mediated rejection group than in the non-antibody-mediated rejection group. The proportion of fFollicular T regulatory cells can effectively modulate the human immune system, but their functions and mechanisms remain poorly understood. Recent studies have demonstrated that the proportion of follicular T regulatory cells is closely associated with chronic antibody-mediated rejection in kidney transplantation. The study included 88 kidney transplant patients, of whom 40 had antibody-mediated rejection and 48 did not. The proportion of follicular T regulatory cells in graft tissue and peripheral blood was significantly lower in the antibody-mediated rejection group compared to the non-antibody-mediated rejection group. The proportion of follicular T helper cells producing IL-21 was significantly elevated.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Functional assays revealed that follicular T regulatory cells can suppress immune function, significantly reducing IL-21 secretion by follicular T helper cells and further inhibiting the proliferation and differentiation of B cells. Blocking CTLA-4, neutralizing IL-10, and inhibiting TGF-\u03b2 diminished this effect. The study also demonstrated that sirolimus reduced the proportion of follicular T regulatory cells, whereas cyclosporine and tacrolimus had no significant impact.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although research on follicular T regulatory cells remains in its early stages, with further mechanisms requiring in-depth exploration, the growing focus on antibody-mediated rejection has spurred increasing studies in this area. It is believed that, in the near future, kidney allograft dysfunction caused by antibody-mediated rejection could be fundamentally transformed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Written by | Zhu Dong, Edited by | Zhu Dong, Photography | G.T.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This article is an original publication of the \u201cKidney Transplantation, Zhongshan Hospital, Fudan University\u201d WeChat public account. Reproduction requires authorization from this account and the original author, with proper attribution. To care for your kidneys, begin by following the \u201cKidney Transplantation, Zhongshan Hospital, Fudan University\u201d WeChat public account. You can also click [Read the Original] to explore <a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE1MjQzNQ==&amp;mid=2652805599&amp;idx=1&amp;sn=d0865acb817a665c561c7ec7bf6a2488&amp;chksm=80fbf043b78c79554f780643bd45d0f1d58043ebefa39f52e06e707bb2ccb832653a7fb8c4ec&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noreferrer noopener\">Homocysteine and Kidney Transplantation<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"686\" height=\"350\" src=\"http:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126.png\" alt=\"\" class=\"wp-image-3672\" style=\"width:750px;height:auto\" srcset=\"https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126.png 686w, https:\/\/www.transplantation.com.cn\/wp-content\/uploads\/2024\/10\/image-126-300x153.png 300w\" sizes=\"auto, (max-width: 686px) 100vw, 686px\" \/><\/figure>\n\n\n\n<div class=\"gspb_button_wrapper gspb_button-id-gsbp-9b0f7c0\" id=\"gspb_button-id-gsbp-9b0f7c0\"><a class=\"wp-block-greenshift-blocks-buttonbox gspb-buttonbox wp-element-button\" href=\"https:\/\/mp.weixin.qq.com\/s\/4o8JpTCI5P2-5RundA_gsA\" title=\"\u5168\u56fd\u9996\u4f8b\u5c3f\u8def\u611f\u67d3\u6cbb\u7597\u6848\u4f8b\" target=\"_blank\" rel=\"noopener\"><span class=\"gspb-buttonbox-textwrap\"><span class=\"gspb-buttonbox-text\"><span class=\"gspb-buttonbox-title\">Read the original article<\/span><\/span><span class=\"gspb-buttonbox-icon\"><svg class=\"\" style=\"display:inline-block;vertical-align:middle\" width=\"15\" height=\"15\" viewBox=\"0 0 896 1024\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path style=\"fill:#565D66\" d=\"M436.202 76.202l-39.598 39.598c-9.372 9.372-9.372 24.568 0 33.942l310.26 310.258h-682.864c-13.254 0-24 10.746-24 24v56c0 13.254 10.746 24 24 24h682.864l-310.26 310.26c-9.372 9.372-9.372 24.568 0 33.942l39.598 39.598c9.372 9.372 24.568 9.372 33.942 0l418.828-418.828c9.372-9.372 9.372-24.568 0-33.942l-418.83-418.828c-9.372-9.374-24.568-9.374-33.94 0z\"><\/path><\/svg><\/span><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- wp:paragraph --><\/p>\n<p><strong>October 28, 2024, Immune Tolerance<\/strong><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image {\"id\":3670,\"width\":\"750px\",\"height\":\"auto\",\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block... \n\n","protected":false},"author":1,"featured_media":3686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 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