{"id":2433,"date":"2024-10-12T18:11:03","date_gmt":"2024-10-12T10:11:03","guid":{"rendered":"http:\/\/zhongshan.wordpress.aibingliben.com\/?p=2433"},"modified":"2025-04-02T11:37:17","modified_gmt":"2025-04-02T03:37:17","slug":"%e5%85%a8%e5%9b%bd%e9%a6%96%e4%be%8b%e5%b0%bf%e8%b7%af%e6%84%9f%e6%9f%93%e6%b2%bb%e7%96%97%e6%a1%88%e4%be%8b","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/en_US\/2024\/10\/12\/%e5%85%a8%e5%9b%bd%e9%a6%96%e4%be%8b%e5%b0%bf%e8%b7%af%e6%84%9f%e6%9f%93%e6%b2%bb%e7%96%97%e6%a1%88%e4%be%8b\/","title":{"rendered":"The First Case of Urinary Tract Infection Treatment in China"},"content":{"rendered":"\n<p>The patient developed complex and recurrent urinary tract infections following bladder tumor surgery. Klebsiella pneumoniae was detected in the patient\u2019s urine in 2014, and prolonged antibiotic treatment led to the development of fully resistant strains of K. pneumoniae in the patient\u2019s body. In January 2018, the patient was officially enrolled in phage therapy. Following diagnosis, the patient\u2019s infection sites were identified in the left and right renal pelvis and bladder, compounded by urinary obstruction, making treatment highly challenging. The first three rounds of intravesical bacteriophage instillation were effective, but pulmonary Gram-negative bacteria could not be eradicated. During treatment, to relieve ureteral obstruction from the renal pelvis to the bladder, the patient underwent double-J stent implantation surgery; however, new strains of Klebsiella pneumoniae re-established infection from the renal pelvis to the bladder shortly after stent insertion and replacement. After specialist consultation, the team decided on a fourth treatment round: pyelostomy followed by bacteriophage irrigation through a stoma tube combined with intravenous antibiotics for one week, followed by discontinuation of antibiotics and continuation of phage therapy for another week, concluding with complete drug withdrawal and one month of continuous observation. Ultimately, the patient\u2019s drug-resistant urinary tract bacteria were eradicated, urinary irritation symptoms improved markedly, and quality of life was significantly enhanced.<\/p>\n\n\n\n<div class=\"gspb_button_wrapper gspb_button-id-gsbp-9b0f7c0\" id=\"gspb_button-id-gsbp-9b0f7c0\"><a class=\"wp-block-greenshift-blocks-buttonbox gspb-buttonbox wp-element-button\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2020.608402\/full\" title=\"\u5168\u56fd\u9996\u4f8b\u5c3f\u8def\u611f\u67d3\u6cbb\u7597\u6848\u4f8b\" target=\"_blank\" rel=\"noopener\"><span class=\"gspb-buttonbox-textwrap\"><span class=\"gspb-buttonbox-text\"><span class=\"gspb-buttonbox-title\">Read the original article<\/span><\/span><span class=\"gspb-buttonbox-icon\"><svg class=\"\" style=\"display:inline-block;vertical-align:middle\" width=\"15\" height=\"15\" viewBox=\"0 0 896 1024\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path style=\"fill:#565D66\" d=\"M436.202 76.202l-39.598 39.598c-9.372 9.372-9.372 24.568 0 33.942l310.26 310.258h-682.864c-13.254 0-24 10.746-24 24v56c0 13.254 10.746 24 24 24h682.864l-310.26 310.26c-9.372 9.372-9.372 24.568 0 33.942l39.598 39.598c9.372 9.372 24.568 9.372 33.942 0l418.828-418.828c9.372-9.372 9.372-24.568 0-33.942l-418.83-418.828c-9.372-9.374-24.568-9.374-33.94 0z\"><\/path><\/svg><\/span><\/span><\/a><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><!-- wp:paragraph --><\/p>\n<p>The patient developed complex and recurrent urinary tract infections following bladder tumor surgery. Klebsiella pneumoniae was detected in the patient\u2019s urine in 2014, and prolonged antibiotic treatment led to the developmen&#8230;<\/p>\n","protected":false},"author":1,"featured_media":2439,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-text{display:flex;flex-direction:column}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{box-sizing:border-box}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap>.gspb-buttonbox-icon{display:flex}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg path{fill:#fff!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg{margin:0!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap{display:flex;flex-direction:row;align-items:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-icon{margin-left:13px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{margin-bottom:0;background-color:#226dc2;cursor:pointer;text-decoration:none;color:#fff;border-style:solid;border-width:1px;border-color:#428ad6;box-shadow:0 2px 4px 0 #0000001a}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox a{text-decoration:none}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb_backgroundOverlay{border-top-left-radius:4px;border-top-right-radius:4px;border-bottom-right-radius:4px;border-bottom-left-radius:4px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover{box-shadow:0 3px 9px 0 #12121226;transform:translateY(-2px)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path{transition:all .25s cubic-bezier(.165,.84,.44,1)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:active,.active #gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{transform:translateY(2px)}","footnotes":""},"categories":[145],"tags":[],"class_list":["post-2433","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-145"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/2433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/comments?post=2433"}],"version-history":[{"count":2,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/2433\/revisions"}],"predecessor-version":[{"id":7122,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/2433\/revisions\/7122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/media\/2439"}],"wp:attachment":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/media?parent=2433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/categories?post=2433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/tags?post=2433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}