{"id":1820,"date":"2024-10-10T10:33:28","date_gmt":"2024-10-10T02:33:28","guid":{"rendered":"http:\/\/zhongshan.wordpress.aibingliben.com\/?p=1820"},"modified":"2025-04-01T18:22:10","modified_gmt":"2025-04-01T10:22:10","slug":"%e4%b8%ba%e4%bd%95%e5%bc%82%e7%a7%8d%e7%a7%bb%e6%a4%8d%e4%b8%93%e5%ae%b6%e5%af%b9%e7%8c%aa%e6%83%85%e6%9c%89%e7%8b%ac%e9%92%9f%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.transplantation.com.cn\/en_US\/2024\/10\/10\/%e4%b8%ba%e4%bd%95%e5%bc%82%e7%a7%8d%e7%a7%bb%e6%a4%8d%e4%b8%93%e5%ae%b6%e5%af%b9%e7%8c%aa%e6%83%85%e6%9c%89%e7%8b%ac%e9%92%9f%ef%bc%9f\/","title":{"rendered":"Why Xenotransplantation Experts Love Pigs?"},"content":{"rendered":"\n

October 10, 2024, Xenotransplantation<\/strong><\/p>\n\n\n\n

Greetings, Kidney Friends!<\/p>\n\n\n\n

The role of pigs in addressing the critical challenge of organ shortage is strikingly prominent, nearly indispensable as allies. But what drives this choice, and why do we prefer pigs over other animals? There must be unique reasons and considerations behind this choice. We\u2019ve discussed this previously, but if you\u2019re interested, refer to: Why Pigs? The Undisputed Star of Xenotransplantation.<\/a>Today, we\u2019ll delve deeper into why monkeys, apes, and other animals popular among our readers aren\u2019t chosen.<\/p>\n\n\n\n

Part One<\/strong>
Although medical scientists have explored using primates like baboons and orangutans as sources for xenotransplantation, pigs have emerged as the priority in clinical trials due to several scientific reasons.<\/p>\n\n\n\n

Part Two<\/strong>
First, pigs are more readily available than primates, which are typically found in zoos. Pigs reproduce rapidly and efficiently. A pig can produce 5\u201312 piglets per litter. It takes just 6 months for a pig to grow to a size suitable for human organ transplantation. In contrast, baboons require 3 to 5 years to reach sexual maturity, produce only one or two offspring per birth, and take 9 years to reach full size.<\/p>\n\n\n\n

Part Three<\/strong>
Second, pig organs are highly similar to human organs in size and physiological function, making them ideal organ donors. As we know, transplantation involves connecting the blood vessels of the donor and recipient. The anatomy and blood circulation of a pig heart resemble those of a human heart, and pig kidneys and livers are comparable to human kidneys and livers, simplifying surgical procedures. Conversely, baboon organs are not large enough for adult human use, akin to a pony pulling a heavy cart, increasing the strain.<\/p>\n\n\n\n

Part Four<\/strong>
Additionally, blood type compatibility is a key consideration in transplantation, but pigs have a relatively simple blood type system, whereas primate organs require more rigorous blood type matching. Simultaneously, pigs are less prone than baboons to acquiring zoonotic diseases following organ transplantation.<\/p>\n\n\n\n

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Image: At Massachusetts General Hospital in Boston, surgeons performed the first transplant of genetically modified pig kidneys into a living person. Michelle Roth\/Massachusetts General Hospital<\/strong><\/p>\n\n\n\n

Overall, pigs were chosen as organ donors due to their similarity to human organs, rapid reproductive rates, and significant advancements in genetic engineering. Collectively, these factors position pigs as a groundbreaking option in xenotransplantation. With advancements in science and technology, we have reason to believe that pig organ transplantation will become increasingly widespread, offering hope to patients awaiting organ transplants.<\/p>\n\n\n\n

That concludes today\u2019s discussion. If you find this article helpful, please follow, like, save, share it with friends, or explore more about kidney transplantation. Until next time.<\/p>\n\n\n\n

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Read the original article<\/span><\/span><\/path><\/svg><\/span><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

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October 10, 2024, Xenotransplantation<\/strong><\/p>\n

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Greetings, Kidney Friends!<\/p>\n

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The role of pigs in addressing the cr…<\/p>\n","protected":false},"author":1,"featured_media":1599,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"#gspb_button-id-gsbp-9b0f7c0{display:flex;justify-content:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-text{display:flex;flex-direction:column}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{box-sizing:border-box}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap>.gspb-buttonbox-icon{display:flex}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover .gspb-buttonbox-icon svg path{fill:#fff!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg{margin:0!important}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb-buttonbox-textwrap{display:flex;flex-direction:row;align-items:center}#gspb_button-id-gsbp-9b0f7c0 .gspb-buttonbox-icon{margin-left:13px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{margin-bottom:0;background-color:#226dc2;cursor:pointer;text-decoration:none;color:#fff;border-style:solid;border-width:1px;border-color:#428ad6;box-shadow:0 2px 4px 0 #0000001a}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox a{text-decoration:none}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox>.gspb_backgroundOverlay{border-top-left-radius:4px;border-top-right-radius:4px;border-bottom-right-radius:4px;border-bottom-left-radius:4px}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:hover{box-shadow:0 3px 9px 0 #12121226;transform:translateY(-2px)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg,#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox .gspb-buttonbox-icon svg path{transition:all .25s cubic-bezier(.165,.84,.44,1)}#gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox:active,.active #gspb_button-id-gsbp-9b0f7c0>.gspb-buttonbox{transform:translateY(2px)}","footnotes":""},"categories":[104],"tags":[],"class_list":["post-1820","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-104"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/1820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/comments?post=1820"}],"version-history":[{"count":1,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/1820\/revisions"}],"predecessor-version":[{"id":7079,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/posts\/1820\/revisions\/7079"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/media\/1599"}],"wp:attachment":[{"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/media?parent=1820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/categories?post=1820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.transplantation.com.cn\/en_US\/wp-json\/wp\/v2\/tags?post=1820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}